MindEmits Blog: Biorad & Randox - QC Product Comparison Review (Lyophilized Clinical Chemistry Control)

Biorad(USA) & Randox (UK) QC are preferred third party Internal Quality Control (IQC) materials in worldwide. They are major key players in the global IVD quality control market. Herewith provided comparison review of Lyophilized Clinical Chemistry Control Material based on product details & kit literature published in their webportal.

The comparison will be useful for Lab Directors,Clinical Biochemists,Medical Biochemists & Medical laboratory professionals to choose easily their QC materials according to Equipment & Test Scope.

S.No	Particulars	Biorad (USA)	Randox (UK)
1.	Product Name	Lyphochek - Assayed Chemistry Control	Acusera – Assayed Chemistry Premium Plus Control
2.	Product Code	Level 1 : C-310-5 Level 2 : C-315-5 Bilevel MiniPak : 313X	Level 2 : HN1530 Level 3 : HE1532 Level 2 & Level 3 : HS2611
3.	Matrix Type	Human Serum , Lyophilized	Human Serum, Lyophilized
4.	QC Levels	Level 1 (Normal), Level 2 (Abnormal)	Level 2 (Normal), Level 3 (High)
5.	Available Pack Sizes	12 × 5 mL – Level 1 12 × 5 mL – Level 2 02 × 5 mL – Level 1 & Level 2	20× 5 mL – Level 2 20× 5 mL – Level 3 2× 5×5 mL – Level 2 & Level 3
6.	Shelf life	3 Years	4 Years
7.	Reconstituted Stability @ 15ºC	Not Provided	8 hours
8.	Reconstituted Stability @ Refrigeration (2-8 ºC)	7 Days Except : - T3 (Free), Acid Phosphatase (Total) and Prostatic Acid Phosphatase (PAP) – 3 Days	7 Days Except: - Bilirubin & Total PSA – 4 days - NEFA – 1 day
9.	Reconstituted Stability @ Frozen (-10 to - 20ºC)	30 Days Except : - Tobramycin : 20 Days - T3 (Free) : 10 Days	28 Days Note : After stabilization Total and Prostatic Acid Phosphatase is stable for 2 hours at +15°C to +25°C, 2 days at +2°C to +8°C, and 28 days when frozen once at –18°C to –24°C.
10.	Reconstituting Material	Distilled Water	Distilled Water
11.	QC Target/Range	+/- 3 SD	+/- 2SD
12.	Total No of Analytes	80 Analytes	70 Analytes

S.No	ANALYTES LIST	Biorad (USA) Lyphochek - Assayed Chemistry Control	Randox (UK) Acusera – Assayed Chemistry Premium Plus Control
1.	Alpha-1-Antitrypsin	✓	✘
2.	Alpha-1-Globulin (Electrophoresis)	✘	✓
3.	Alpha-2-Globulin (Electrophoresis)	✘	✓
4.	Alpha-Hydroxybutyrate Dehydrogenase (αHBDH)	✓	✓
5.	Acetaminophen	✓
6.	Acid Phosphatase (Total)	✓	✓
7.	Acid Phosphatase (Prostatic)	✘	✓
8.	Acid Phosphatase (Non-Prostatic)	✘	✓
9.	Alphafetoprotein (AFP)	✓	✘
10.	Albumin	✓	✓
11.	Albumin (Electrohoresis)	✘	✓
12.	Alkaline Phosphatase (ALP)	✓	✓
13.	ALT/SGPT	✓	✓
14.	Amylase	✓	✓
15.	Amylase (Alpha)	✓	✘
16.	Amylase (Pancreatic)	✓	✓
17.	Apolipoprotein A-1	✓	✓
18.	Apolipoprotein B	✓	✓
19.	AST/SGOT	✓	✓
20.	Beta-1-Globulin (Electrophoresis)	✘	✓
21.	Bile Acids	✘	✓
22.	Bilirubin (Direct)	✓	✓
23.	Bilirubin (Indirect) Bilirubin (Total)	✓	✓
24.	Calcium	✓	✓
25.	Calcium (Ionized)	✓	✘
26.	Carbamazepine	✓	✘
27.	CEA	✓	✘
28.	Ceruloplasmin	✓	✘
29.	Chloride	✓	✓
30.	Cholesterol (HDL)	✓	✓
31.	Cholesterol (LDL)	✓	✘
32.	Cholesterol (Total)	✓	✓
33.	Cholinesterase	✓	✓
34.	CO2	✓	✓
35.	Complement C3	✓	✘
36.	Complement C4	✓*	✘
37.	Copper	✓	✓
38.	Cortisol	✓	✓
39.	Creatine Kinase (CK)	✓	✓
40.	Creatinine	✓	✓
41.	D-3-Hydroxybutyrate	✘	✓
42.	Digoxin	✓	✓
43.	Folate	✘	✓
44.	Gentamicin	✓	✓
45.	GGT	✓	✓
46.	GLDH	✓	✓
47.	Globulin	✓	✘
48.	Gamma-Globulin (Electrophoresis)	✘	✓
49.	Glucose	✓	✓
50.	Haptoglobin	✓	✘
51.	hCG-β Subunit	✓	✘
52.	Immunoglobulin A (IgA)	✓	✓
53.	Immunoglobulin G (IgG)	✓	✓
54.	Immunoglobulin M (IgM)	✓	✓
55.	Iron	✓	✓
56.	Iron (UIBC)	✓	✘
57.	Lactate (Lactic Acid)	✓	✓
58.	LAP-Arylamidase	✓	✓
59.	LDH	✓	✓
60.	Lipase	✓	✓
61.	Lithium	✓	✓
62.	Magnesium	✓	✓
63.	NEFA	✘	✓
64.	Osmolality	✓	✓
65.	Paracetamol	✘	✓
66.	PAP	✓	✘
67.	Phenobarbital	✓	✘
68.	Phenytoin	✓	✘
69.	Phosphorus	✓	✓
70.	Potassium	✓	✓
71.	Protein Electrophoresis	✓	✘
72.	Protein Total	✘	✓
73.	Protein (Total) PSA	✓	✓
74.	Salicylate	✓	✓
75.	Sodium	✓	✓
76.	T3 (Free)	✓	✘
77.	T3 (Total)	✓	✓
78.	T3 Uptake/T-Uptake	✓	✘
79.	T4 (Free)	✓	✓
80.	T4 (Total)	✓	✓
81.	TBG	✓	✘
82.	Theophylline	✓	✓
83.	Tobramycin	✓	✓
84.	Transferrin	✓	✓
85.	Triglycerides	✓	✓
86.	Thyroid Stimulating Hormone (TSH)	✓	✓
87.	TIBC	✘	✓
88.	Urea	✓	✓
89.	Urea Nitrogen	✓	✘
90.	Uric Acid	✓	✓
91.	Valproic Acid	✓	✘
92.	Vancomycin	✓	✘
93.	Vitamin B12	✓	✓
94.	Zinc	✓	✓
		Note : * No Claim is made for expected value or stability

S.No	INSTRUMENTS LIST	Biorad (USA) Lyphochek - Assayed Chemistry Control	Randox (UK) Acusera – Assayed Chemistry Premium Plus Control
1.	ABAXIS-PICCOLO	✓	✘
2.	ABX PENTRA 400	✘	✓
3.	ABBOTT ARCHITECT cSYSTEMS	✓	✓
4.	BECKMAN COULTER ACCESS / 2 / 2i	✓	✘
5.	BECKMAN COULTER AU SYSTEMS	✓	✓
6.	BECKMAN COULTER SYNCRON/UniCel DxC SERIES	✓	✓
7.	BIOSYSTEMS A15	✘	✓
8.	BIOSYSTEMS A25	✘	✓
9.	BIOTECHNICA/WIENER BT & CB SERIES	✘	✓
10.	ELITECH/VITALAB SELECTRA SERIES	✘	✓
11.	ILAB 600 /650 /ARIES/TAURUS	✘	✓
12.	KONELAB 20/30/60/THERMO SCIENTIFIC INDIKO PLUS	✘	✓
13.	MINDRAY BS-200/300/400	✘	✓
14.	ORTHO VITROS SERIES	✓	✓
15.	ROCHE / HITACHI COBAS C SYSTEMS	✓	✓
16.	ROCHE COBAS INTEGRA	✓	✓
17.	RANDOX RX SERIES	✘	✓
18.	SIEMENS ADVIA CENTAUR CP	✓	✘
19.	SIEMENS ADVIA CENTAUR SYSTEMS	✓	✘
20.	SIEMENS ADVIA CHEMISTRY SYSTEMS	✓	✓
21.	SIEMENS ATELLICA CHEMISTRY SYSTEMS	✘	✓
22.	SIEMENS BN SERIES NEPHELOMETERS	✓	✘
23.	SIEMENS DIMENSION SERIES	✓	✓
24.	SIEMENS DIMENSION VISTA SYSTEMS	✓	✓
25.	SIEMENS IMMULITE / IMMULITE 1000	✓	✘
26.	SIEMENS IMMULITE 2000 / 2000 XPi	✓	✘
		Note: Target Values can be obtained from “Method List” for Equipment not listed.	Note: Target Values can be obtained from “Mean of All Instruments” for Equipment not listed.